Highly Effective Oral Amphotericin B Formulation against Murine Visceral Leishmaniasis
نویسندگان
چکیده
منابع مشابه
A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model
PURPOSE To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL). METHODS The stability testing of four novel oral lipid AmB formulations composed of mono- and di-glycerides and pegylated esters (iCo-010 to iCo-013) was performed over 60 d and...
متن کاملNovel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature.
PURPOSE To evaluate the antifungal activity of amphotericin B (AmB) in a mouse model of systemic candidiasis following administration of a novel oral AmB formulation (iCo-010) that has been pre-exposed to tropical temperatures. METHODS Amphotericin B (AmB) was prepared as a 5 mg/mL dispersion in a mixture of Peceol, Gelucire 44/14 and VitE-TPGS 2,3 (iCo-010). The formulation was protected fro...
متن کاملAmphotericin B in resistant visceral leishmaniasis.
Sodium stibogluconate (SSG) in the dose of 20 mg/kg body weight daily intramuscularly for 20-30 days is recommended by WHO as the first line drug for Indian visceral leishmaniasis (VL). Relapses following therapy and unresponsiveness to the higher doses of SSG are still a problem in north Bihar. Serious toxicity of SSG including myocarditis, sudden death and renal failure have also been reporte...
متن کاملTwo doses of a lipid formulation of amphotericin B for the treatment of Mediterranean visceral leishmaniasis.
To evaluate the efficacy of a short course of a lipid formulation of amphotericin B (L-AmB) for the treatment of Mediterranean visceral leishmaniasis (VL), an open prospective study was conducted. Forty-one children with parasitologically confirmed leishmaniasis received L-AmB, 10 mg/kg daily for 2 days. The comparison groups were 30 children who, in a previous study, were treated with L-AmB, 4...
متن کاملLiposomal Amphotericin B for the Treatment of Visceral Leishmaniasis
Caryn Bern, Jill Adler-Moore, Juan Berenguer, Marleen Boelaert, Margriet den Boer, Robert N. Davidson, Concepcion Figueras, Luigi Gradoni, Dimitris A. Kafetzis, Koert Ritmeijer, Eric Rosenthal, Catherine Royce, Rosario Russo, Shyam Sundar, and Jorge Alvar Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; California State Polytechnic University, Pomona...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2009
ISSN: 0022-1899,1537-6613
DOI: 10.1086/600105